Study on crystallinity and compactibility of binary mixture of analgesic
substances with Microcrystalline cellulose
Department
of Pharmaceutics, Airlangga University, Surabaya, Indonesia
Abstract
Objectives:
The aim of this study was to investigate crystallinity and compatibility
transformation of two binary mixtures of analgesic substance with excipient due
to mixing and compression. Methods: Analgesic substances used in this study
were mefenamic acid (MA) and acetaminophen (AC). Each substance was mixed with
microcrystalline selolusa as excipient with drug-excipient ratio of 70:30,
80:20 and 90:10 %w/w then compressed with pressure of 29.4 kN. Characterization
was done by Powder X-Ray Diffraction (PXRD), thermal analysis (DTA), FTIR
spectrometer and a Scanning Electron Microscope (SEM). Mechanical properties
was also evaluated by calculating its tensile strength Results: Evaluation of
crystallites size of MA and MA-MCC mixture showed that the value of MA
crystallite size is relatively fixed in all the peaks observed. Crystallite
size of the AC and AC-MCC mixture also showed similar results with MA. From the
elastic modulus curve, it was recognized that the tensile strength of MA is
greater than AC, it indicates that the MA is more plastic than AC. Conclution:
X-ray powder diffraction of binary mixture indicated that intensity of both MA
and AC decreased with increasing amount of MCC. The average crystallite size
were 15-19 Å (MA) and 21-30 Å (AC). It was known that MA has compactibility
better than AC.
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